Associations between urinary phthalate concentrations and semen quality parameters in a general population

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Associations between urinary phthalate concentrations and semen quality parameters in a general population.

STUDY QUESTION Are urinary phthalate concentrations associated with altered semen quality parameters among males recruited from the general population? SUMMARY ANSWER Urinary levels of metabolites of phthalate diesters are associated with lower total sperm counts, larger sperm head sizes, and higher percentages of morphologically abnormal sperm. WHAT IS KNOWN ALREADY High dose experiments i...

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Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites.

BACKGROUND Phthalates are multifunctional chemicals used in a variety of consumer, medical, and personal care products. Previously, we reported dose-response associations of decreased semen quality with urinary concentrations of monobutyl phthalate (MBP) and monobenzyl (MBzP) phthalate, which are metabolites of dibutyl phthalate and butylbenzyl phthalate, respectively. The present study extends...

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Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters

BACKGROUND Organophosphates are broad class of chemicals widely used as pesticides throughout the world. We performed a cross-sectional study of associations between dialkylphosphate metabolites of organophosphates and semen quality among pesticide applicators in Majes (Arequipa), Peru. METHODS Thirty-one men exposed to organophosphate (OP) pesticides and 31 non-exposed were recruited (age, 2...

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Urinary Concentrations of Parabens and Serum Hormone Levels, Semen Quality Parameters, and Sperm DNA Damage

BACKGROUND Parabens are commonly used as antimicrobial preservatives in cosmetics, pharmaceuticals, and food and beverage processing. Widespread human exposure to parabens has been recently documented, and some parabens have demonstrated adverse effects on male reproduction in animal studies. However, human epidemiologic studies are lacking. OBJECTIVE We investigated relationships between uri...

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Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy

BACKGROUND Maintaining thyroid homeostasis during pregnancy is essential for normal fetal growth and development. Growing evidence suggests that phthalates interfere with normal thyroid function. Few human studies have investigated the degree to which phthalates may affect thyroid hormone levels in particularly susceptible populations such as pregnant women. OBJECTIVES We examined the associa...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2015

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/dev219